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"In the midst of winter I finally learned that there was in me an invincible summer."

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Wednesday, August 29, 2012

AIDS-Like Disease In Asians: Not Contagious, But Damages Immune System


Researchers have identified a mysterious new disease that has left scores of people in Asia and some in the United States with AIDS-like symptoms even though they are not infected with HIV.

The patients' immune systems become damaged, leaving them unable to fend off germs as healthy people do. What triggers this isn't known, but the disease does not seem to be contagious.

This is another kind of acquired immune deficiency that is not inherited and occurs in adults, but doesn't spread the way AIDS does through a virus, said Dr. Sarah Browne, a scientist at the National Institute of Allergy and Infectious Diseases.

She helped lead the study with researchers in Thailand and Taiwan where most of the cases have been found since 2004.

Their report is in Thursday's New England Journal of Medicine.
 
It's still possible that an infection of some sort could trigger the disease, even though the disease itself doesn't seem to spread person-to-person, he said.

The disease develops around age 50 on average but does not run in families, which makes it unlikely that a single gene is responsible, Browne said. 

Some patients have died of overwhelming infections, including some Asians now living in the U.S., although Browne could not estimate how many.
  

AIDS is a specific disease, and it stands for acquired immune deficiency syndrome. That means the immune system becomes impaired during someone's lifetime, rather than from inherited gene defects like the "bubble babies" who are born unable to fight off germs.

The virus that causes AIDS – HIV – destroys T-cells, key soldiers of the immune system that fight germs. The new disease doesn't affect those cells, but causes a different kind of damage.

 Browne's study of more than 200 people in Taiwan and Thailand found that most of those with the disease make substances called autoantibodies that block interferon-gamma, a chemical signal that helps the body clear infections.

Blocking that signal leaves people like those with AIDS – vulnerable to viruses, fungal infections and parasites, but especially micobacteria, a group of germs similar to tuberculosis that can cause severe lung damage.


Researchers are calling this new disease an "adult-onset" immunodeficiency syndrome because it develops later in life and they don't know why or how.

"Fundamentally, we do not know what's causing them to make these antibodies," Browne said.

Antibiotics aren't always effective, so doctors have tried a variety of other approaches, including a cancer drug that helps suppress production of antibodies.

The disease quiets in some patients once the infections are tamed, but the faulty immune system is likely a chronic condition, researchers believe.

The fact that nearly all the patients so far have been Asian or Asian-born people living elsewhere suggests that genetic factors and something in the environment such as an infection may trigger the disease, researchers conclude.

The first cases turned up in 2004 and Browne's study enrolled about 100 people in six months.

"We know there are many others out there," including many cases mistaken as tuberculosis in some countries, she said.

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Blogger Comments:  This disease is interesting because it affects the immune system... maybe in studying this disease,  researchers will find drugs that will be useful for treating M.S.  Many drugs are discovered when experimenting for one disease that go on to be useful in a completely different disease.


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AIDS-Like Disease In Asians: Not Contagious, But Damages Immune System

Link:  http://www.huffingtonpost.com/2012/08/22/aids-like-disease-asians-immune-system_n_1823296.html







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