Intensive lifestyle changes may affect the progressio... [J Urol. 2005] - PubMed - NCBI

 This study is mentioned in the 'Optimal Diet' article by Dean Ornish that is recorded in this blog.

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J Urol. 2005 Sep;174(3):1065-9; discussion 1069-70.

Intensive lifestyle changes may affect the progression of prostate cancer.

Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, Dunn-Emke S, Crutchfield L, Jacobs FN, Barnard RJ, Aronson WJ, McCormac P, McKnight DJ, Fein JD, Dnistrian AM, Weinstein J, Ngo TH, Mendell NR, Carroll PR.

Source

Department of Medicine, Preventive Medicine Research Institute, University of California-San Francisco, 94965, USA. d.ornish@pmri.org

Abstract

PURPOSE:

Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year.

MATERIALS AND METHODS:

Patient recruitment was limited to men who had chosen not to undergo any conventional treatment, which provided an unusual opportunity to have a nonintervention randomized control group to avoid the confounding effects of interventions such as radiation, surgery or androgen deprivation therapy. A total of 93 volunteers with serum PSA 4 to 10 ng/ml and cancer Gleason scores less than 7 were randomly assigned to an experimental group that was asked to make comprehensive lifestyle changes or to a usual care control group.

RESULTS:

None of the experimental group patients but 6 control patients underwent conventional treatment due to an increase in PSA and/or progression of disease on magnetic resonance imaging. PSA decreased 4% in the experimental group but increased 6% in the control group (p = 0.016). The growth of LNCaP prostate cancer cells (American Type Culture Collection, Manassas, Virginia) was inhibited almost 8 times more by serum from the experimental than from the control group (70% vs 9%, p <0 .001=".001" also="also" and="and" associated="associated" cell="cell" change="change" changes="changes" degree="degree" diet="diet" growth="growth" in="in" lifestyle.="lifestyle." lncap="lncap" of="of" p="p" psa="psa" serum="serum" significantly="significantly" the="the" were="were" with="with">

CONCLUSIONS:

Intensive lifestyle changes may affect the progression of early, low grade prostate cancer in men. 

Further studies and longer term followup are warranted.

PMID:

16094059

[PubMed - indexed for MEDLINE]

Intensive lifestyle changes may affect the progressio... [J Urol. 2005] - PubMed - NCBI