DRUGS and MEDICATIONS
Gilenya
GENERIC NAME(S): FINGOLIMOD HCL
GENERIC NAME(S): FINGOLIMOD HCL
Alert The FDA is investigating a possible link between Gilenya and a case of a rare brain infection in one patient.
Uses
This medication is used to treat a certain type of multiple sclerosis (relapsing-remitting multiple sclerosis-MS). It is not a cure for MS but it is thought to help by preventing immune system cells (lymphocytes) from attacking the nerves in your brain and spinal cord. It helps decrease the number of episodes of worsening and may prevent or delay disability.
How to use Gilenya
Read the Medication Guide provided by your pharmacist before you start taking fingolimod and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Before starting fingolimod, your doctor will do medical/laboratory tests (such as complete blood count,blood pressure, EKG, pulse) to monitor for side effects.
Take this medication by mouth with or without food as directed by your doctor, usually once a day. You will be monitored for at least 6 hours after the first dose to make sure your heartbeat does not go too slow. A very slow heartbeat increases the risk for a serious heartrhythm problem (QT prolongation in the EKG).
Tell your doctor if you have low levels of magnesium/potassium in the blood, personal or family history of QT prolongation in the EKG, family history of sudden cardiac death, or heart failure. Also tell your doctor if you are taking other drugs that can slow down your heartbeat or affect heart rhythm (such as causing QT prolongation in the EKG). See also Drug Interactions section.
If you temporarily stop taking fingolimod after starting treatment, you may need to be monitored again for at least 6 hours after you restart this medication. Ask your doctor for details.
Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Tell your doctor if your condition does not improve or if it worsens.
If you temporarily stop taking fingolimod after starting treatment, you may need to be monitored again for at least 6 hours after you restart this medication. Ask your doctor for details.
Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Tell your doctor if your condition does not improve or if it worsens.
How it works:
What conditions does Gilenya treat?
Gilenya prevents the T-cells, the immune cells, from getting out of the lymph nodes. I tell my patients it's like the "roach motel" model of immunity. They can check in, but they can't check out.
The T-cells can't get out of lymph nodes and into the blood. If they can't get into the blood, they can't get into the nervous system.
Side Affects:
Gilenya has known side effects of liver enzyme elevations [potentially causing liver disease], lowering of the white blood cell count [reducing infection-fighting ability], and slowing the heart rate.
A year or so after it came out, there were sudden deaths. These were people who had pre-existing heart problems or were on heartmedication. So they had to change the labeling. Now, if someone has certain types of heart conditions or is on certain types of heart medication, Gilenya is not prescribed.
Gilenya has known side effects of liver enzyme elevations [potentially causing liver disease], lowering of the white blood cell count [reducing infection-fighting ability], and slowing the heart rate.
A year or so after it came out, there were sudden deaths. These were people who had pre-existing heart problems or were on heartmedication. So they had to change the labeling. Now, if someone has certain types of heart conditions or is on certain types of heart medication, Gilenya is not prescribed.
What conditions does Gilenya treat?
Relaxing and Remitting types of m.s.
Source:
http://www.webmd.com/drugs/2/drug-154676/gilenya+oral/details
Source:
http://www.webmd.com/drugs/2/drug-154676/gilenya+oral/details
No comments:
Post a Comment