Fun Stuff

Piclogy ‏@Piclogy

Ice cave under the Athabasca Glacier, Alberta, Canada | Photography by ©Jeff Wallace

 

 

 

The funeral that was led by Darth Vader. http://mentalfloss.com/uk/death/31285/the-funeral-that-was-led-by-darth-vader …

 

Mental Floss UK Verified account ‏@mentalflossuk

Watch this tortoise reign over its Jurassic Park habitat. http://mentalfloss.com/uk/animals/42122/watch-this-tortoise-reign-over-its-jurassic-park-habitat …

 

 

5 true accounts of people being raised by animals. http://mentalfloss.com/uk/people/42088/5-true-accounts-of-children-being-raised-by-animals …

Mental Floss UK Verified account ‏@mentalflossuk

What are the most edited Wikipedia pages? http://mentalfloss.com/uk/internet/42138/what-are-the-most-edited-wikipedia-pages …

Why you'll never be as lazy as a panda. http://mentalfloss.com/uk/animals/31272/why-youll-never-be-as-lazy-as-a-panda …

Mental Floss UK ‏@mentalflossuk May 2

Study confirms that living near water can reduce stress. http://mentalfloss.com/uk/health/42050/study-confirms-what-we-already-knew-living-near-water-can-reduce-stress …

This sheepdog walked 240 miles back to its former home. http://mentalfloss.com/uk/animals/41892/sheepdog-walks-240-miles-back-to-former-home …

Encouragement

 

 It's hard learning who you are all over again. Multiple Sclerosis changes you 









 






 

Restless Leg Syndrome: A frustrating symptom of MS - http://go.shr.lc/1N3fHv9 via @moderndayms

 









 


Not all sicknesses look the same 
 

Genentech ‏@genentech 
#Multiplesclerosis is usually thought of as 1 disease, but its course and symptoms may vary. #MSawarenessmonth







 

We can only do the best we can





Kiss M.S GOODBYE! ‏@KissMSGOODBYE 
M.S gets on my nerves! #ENDMS#CureMS#MultipleSclerosis











 














 
A disability that no one can see is draining beyond belief

#MultipleSclerosis#invisibleillness#AutoimmuneDisease

Remyelinating drug Saving nerves

Sunday, 1 May 2016

Remyelinating drug Saving nerves

Wootla B, Denic A, Warrington AE, Rodriguez M.A monoclonal natural human IgM protects axons in the absence of remyelination. J Neuroinflammation. 2016 ;13(1):94.
BACKGROUND:Whereas demyelination underlies early neurological symptoms in multiple sclerosis (MS), axonal damage is considered critical for permanent chronic deficits. Intracerebral infection of susceptible mouse strains with Theiler's murine encephalomyelitis virus (TMEV) results in chronic induced demyelinating disease (TMEV-IDD) with progressive axonal loss and neurologic dysfunction similar to progressive forms of MS. We previously reported that treatment of chronic TMEV-IDD mice with a neurite outgrowth-promoting natural human antibody, HIgM12, improved brainstem NAA concentrations and preserved functional motor activity. In order to translate this antibody toward clinical trial, we generated a fully human recombinant form of HIgM12, rHIgM12, determined the optimal in vivo dose for functional improvement in TMEV-IDD, and evaluated the functional preservation of descending spinal cord axons by retrograde labeling.
FINDINGS: SJL/J mice at 45 to 90 days post infection (dpi) were studied. A single intraperitoneal dose of 0.25 mg/kg of rHIgM12 per mouse is sufficient to preserve motor function in TMEV-IDD. The optimal dose was 10 mg/kg. rHIgM12 treatment protected the functional transport in spinal cord axons and led to 40 % more Fluoro-Gold-labeled brainstem neurons in retrograde transport studies. This suggests that axons are not only present but also functionally competent. rHIgM12-treated mice also contained more mid-thoracic (T6) spinal cord axons than controls.
CONCLUSIONS:This study confirms that a fully human recombinant neurite outgrowth-promoting monoclonal IgM is therapeutic in a model of progressive MS using multiple reparative readouts. The minimum effective dose is similar to that of a remyelination-promoting monoclonal human IgM discovered by our group that is presently in clinical trials for MS.

The TMEV model has been a model of viral induced demyelination and now it is claimed that it is a model of progressive MS. I am not sure on what grounds. It has nerve loss?

This study says that one delivery of antibody stops 40% nerve loss, which sounds great. If they had done more the mouse's immune system would have got rid of it, but one injection and it saves the brain..great 

Maybe it is time that this approach was put to the test. One injection should be all that is needed. 

I first saw this approach well over a decade ago and we are still awaiting the human results.

 

 

 

 Link: http://multiple-sclerosis-research.blogspot.com/2016/05/remyelinating-drug-saving-nerves.html

 

Tidbits of random info

Nisargadatta Maharaj ‏@Nisargadatta_M 

What have you to wait for when it is already here and now? You have only to look and see. Look at your self, at... http://fb.me/2I9YgWpZS

Corgi

Racoon

 

NaturalHistoryMuseum ‏@NHM_London 

Happy #EarthDay - here's a quick reminder of why our remarkable planet is worth protecting: http://www.nhm.ac.uk/discover/factfile-earth.html?utm_source=tw-20160422&utm_medium=social&utm_campaign=otherworlds …

The brain dictionary

Editor's summary  

It is thought that the meanings of words and language are represented in a semantic system distributed across much of the cerebral cortex. However, little is known about the detailed functional and anatomical organization of this network. Alex Huth, Jack Gallant and colleagues set out to map the functional representations of semantic meaning in the human brain using voxel-based modelling of functional magnetic resonance imaging (fMRI) recordings made while subjects listened to natural narrative speech. They find that each semantic concept is represented in multiple semantic areas, and each semantic area represents multiple semantic concepts. The recovered semantic maps are largely consistent across subjects, however, providing the basis for a semantic atlas that can be used for future studies of language processing. 

An interactive version of the atlas can be explored at http://gallantlab.org/huth2016

Where exactly are the words in your head? Scientists have created an

interactive map showing which brain areas respond to hearing different

words. The map reveals how language is spread throughout the cortex and

across both hemispheres, showing groups of words clustered together by

meaning. The beautiful interactive model allows us to explore the

complex organization of the enormous dictionaries in our heads.

Explore the brain model for yourself here: http://gallantlab.org/huth2016

Read the paper here: http://www.nature.com/doifinder/10.10...

28th April 2016

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  Category  Science + Technology
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  License  Standard YouTube License

  
  
  Link: https://youtu.be/k61nJkx5aDQ
  
  
  
  
  source: http://www.nature.com/nature/videoarchive/brain-dictionary/index.html