Stay Positive


"In the midst of winter I finally learned that there was in me an invincible summer."

- Alert Camus








Sunday, September 28, 2014

Fish and your Brain



Friday, September 19, 2014

MILK is for babies


Will this be the next GOT MILK ad?
{Michaelangelo's creation of Adam as painted on the ceiling of
the Sistine Chapel at the Vatican in Rome}





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Wednesday, September 17, 2014

Multiple Sclerosis International Federation, MSIF

 What we do 



Our projects and programmes are truly international, involving experts and key volunteers from countries across the globe.



Our four main areas of work are international research, supporting MS organisations, advocating for and raising awareness of MS, and communicating MS information.



We aim to communicate accurate, independent and free information about MS to anyone affected by MS around the world, including:
  • People with MS and their families
  • Healthcare professionals who work with people with MS, including neurologists, general practice doctors, MS nurses and physiotherapists
  • MS organisations who are supporting people with MS in their country or region
  • MS researchers






Link: http://www.msif.org/about-us/default.aspx




Journal of Clinical Sleep Medicine - Research & Review Articles in Sleep Medicine



The Underdiagnosis of Sleep Disorders in Patients with Multiple Sclerosis. 1025-1031.

Steven D. Brass, M.D., M.P.H., M.B.A.1; Chin-Shang Li, Ph.D.2; Sanford Auerbach, M.D., F.A.A.S.M.3

BRIEF SUMMARY

Current Knowledge/Study Rationale: Sleep disorders in Multiple Sclerosis patients are reportedly common but the epidemiological data on prevalence is limited to small sample sizes. The rationale for this study was to report on a large population level the prevalence of restless legs syndrome, insomnia, and the risk of obstructive sleep apnea in subjects with Multiple Sclerosis patients using validated screening questionnaires.

Study Impact: Greater than 70% of MS subjects in this large population based survey screened positive for one or more sleep disorders. The vast majority of these sleep disorders are potentially undiagnosed and untreated. Physicians treating patients with Multiple Sclerosis need to be diligent in the screening, evaluation and management of sleep disorders in this population as untreated sleep disorders may impact the fatigue and quality of life of the individual.


Journal of Clinical Sleep Medicine - Research & Review Articles in Sleep Medicine:



Link: http://www.aasmnet.org/jcsm/





About Journal of Clinical Sleep Medicine (JCSM)

Current Knowledge/Study Rationale: Sleep disorders in Multiple Sclerosis patients are reportedly common but the epidemiological data on prevalence is limited to small sample sizes. The rationale for this study was to report on a large population level the prevalence of restless legs syndrome, insomnia, and the risk of obstructive sleep apnea in subjects with Multiple Sclerosis patients using validated screening questionnaires.
Study Impact: Greater than 70% of MS subjects in this large population based survey screened positive for one or more sleep disorders. The vast majority of these sleep disorders are potentially undiagnosed and untreated. Physicians treating patients with Multiple Sclerosis need to be diligent in the screening, evaluation and management of sleep disorders in this population as untreated sleep disorders may impact the fatigue and quality of life of the individual.




Link: http://www.aasmnet.org/JCSM/About.aspx




Sleep disorders widely undiagnosed in individuals with multiple sclerosis


UC Davis study finds sleep disorders widely undiagnosed in individuals with multiple sclerosis



In what may be the largest study of sleep problems among individuals with multiple sclerosis (MS), researchers at UC Davis have found that widely undiagnosed sleep disorders may be at the root of the most common and disabling symptom of the disease: fatigue.


Sacramento, CA (PRWEB) September 12, 2014



In what may be the largest study of sleep problems among individuals with multiple sclerosis (MS), researchers at UC Davis have found that widely undiagnosed sleep disorders may be at the root of the most common and disabling symptom of the disease: fatigue.



Conducted in over 2,300 individuals in Northern California with multiple sclerosis, the large, population-based study found that, overall, more than 70 percent of participants screened positive for one or more sleep disorders.


The research highlights the importance of diagnosing the root causes of fatigue among individuals with MS, as sleep disorders may affect the course of the disease as well as the overall health and well-being of sufferers, the authors said.



The study “The Underdiagnosis of Sleep Disorders in Patients with Multiple Sclerosis,” is published online today in the Journal of Clinical Sleep Medicine.



“A large percentage of MS subjects in our study are sleep deprived and screened positive for one or more sleep disorders,” said Steven Brass, associate clinical professor and director of the Neurology Sleep Clinical Program and co-medical director of the UC Davis Sleep Medicine Laboratory.



“The vast majority of these sleep disorders are potentially undiagnosed and untreated,” he said. “This work suggests that patients with MS may have sleep disorders requiring independent diagnosis and management.”



Fatigue is the hallmark of multiple sclerosis, an inflammatory disease affecting the white matter and spinal cord of sufferers. MS symptoms include loss of vision, vertigo, weakness and numbness. Patients also may experience psychiatric symptoms. Disease onset generally is between the ages of 20 and 50 years. The cause of MS is not known, although it is believed to be an autoimmune condition.



Sleep disorders are known to occur more frequently among patients with MS. To gauge the extent of sleep disorders, such as obstructive sleep apnea and insomnia. Brass and his colleagues surveyed members of the Northern California Chapter of the National MS Society. Subjects were recruited in 2011.



More than 11,000 surveys were mailed to prospective participants. Of those, 2,375 met criteria and were included in the study. Consistent with the reported epidemiology of multiple sclerosis, the majority (81 percent) were female and Caucasian (88 percent). The mean age of the participants was 54.



Participants were asked to complete a 10-page survey, which included a detailed sleep history and questions assessing obstructive sleep apnea, daytime sleepiness, insomnia and restless legs syndrome.



Most of the participants - nearly 52 percent - said it took them more than one half hour to fall asleep at night, and nearly 11 percent reported taking a medication to fall asleep. Close to 38 percent of participants screened positive for obstructive sleep apnea. Nearly 32 percent had moderate to severe insomnia and nearly 37 percent had restless legs syndrome.



However, most of the participants had not been diagnosed with a sleep disorder by a physician. While nearly 38 percent reported having obstructive sleep apnea, only a little more than 4 percent reported being diagnosed by a physician with the condition. Similar statistics were seen for other sleep disorders.



“This study shows that sleep disorder frequency, sleep patterns and complaints of excessive daytime sleepiness suggest that sleep problems may be a hidden epidemic in the MS population, separate from MS fatigue,” Brass said.



Other study authors include Chin-Shang Li of UC Davis and Sanford Auerbach of Boston University.



The study was funded by a grant from the National Center for Advancing Translational Sciences and the National Institutes of Health through grant UL1 TR000002.



UC Davis Health System is improving lives and transforming health care by providing excellent patient care, conducting groundbreaking research, fostering innovative, interprofessional education, and creating dynamic, productive partnerships with the community. The academic health system includes one of the country's best medical schools, a 619-bed acute-care teaching hospital, a 1000-member physician's practice group and the new Betty Irene Moore School of Nursing. It is home to a National Cancer Institute-designated comprehensive cancer center, an international neurodevelopmental institute, a stem cell institute and a comprehensive children's hospital. Other nationally prominent centers focus on advancing telemedicine, improving vascular care, eliminating health disparities and translating research findings into new treatments for patients. Together, they make UC Davis a hub of innovation that is transforming health for all. For more information, visit healthsystem.ucdavis.edu.















































































































































































































































































































UC Davis study finds sleep disorders widely undiagnosed in individuals with multiple sclerosis:









Link: http://www.prweb.com/releases/2014/09/prweb12167287.htm



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Newsroom at UC Davis Health System



The UC Davis Health System newsroom provides the latest health, medical, science and research news for the entire health system. From research funding and findings, to students, faculty and health care leaders in the news, to stories about the innovative ways we are delivering health care to the surrounding communities, the newsroom is your comprehensive source for what is happening at UC Davis Health System.


Newsroom at UC Davis Health System



http://healthsystem.ucdavis.edu




Tuesday, September 16, 2014

Positive Thought




MS Survival Guide | Living with Multiple Sclerosis



CATEGORIES



MS Survival Guide | Living with Multiple Sclerosis:



Link: http://mssurvivalguide.com/

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Sleep Disorders and Latest M.S. News

Sleep disorders are widely undiagnosed in patients with multiple sclerosis
 


3 Surprising Things That Can Affect Multiple Sclerosis - Milwaukee Community Journal
 



There is no describing the invisible symptoms…you can’t tell something is wrong with me just looking at me:

View on webAnd don't forget to check out our latest special, The top 10 best-selling multiple sclerosis drugs of 2013
Just updated: Multiple Sclerosis Practice Essentials. A quick, comprehensive guide for diagnosis and treatment.
 
Could targeting Epstein-Barr virus infection work as an intervention against multiple sclerosis?
 
Brain Signals Move Paralyzed Limbs: Researchers at Cornell University have developed a new model for brain-mac...
How Temperature Affects People With Multiple Sclerosis
 
Vitamin D deficiency is common among pregnant women with multiple sclerosis, study finds
 
 
Embedded image permalink



For multiple sclerosis sufferers, an anxious hope - Boston Globe: Boston GlobeFor multiple sclerosis sufferers...



Sunday, September 14, 2014

Do We Need Doctors Or Algorithms? | TechCrunch







Link: http://techcrunch.com/2012/01/10/doctors-or-algorithms/

Do We Need Doctors Or Algorithms? | TechCrunch: "Do We Need Doctors Or Algorithms?
Posted Jan 10, 2012 by Vinod Khosla"



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Multiple Sclerosis Discovery Forum

Home | Multiple Sclerosis Discovery Forum:



http://www.msdiscovery.org/



 "Stem Cells Stop the Train of MS Damage in Mice
Neural precursors derived from mature tissues rebuild myelin in mic
e with EAE.

CREDIT: CECILIA LATERZA
PREV | NEXT"



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Coping With Stress: Cognitive-Behavioral Stress Reduction


Published on Aug 31, 2012
(Visit: http://www.uctv.tv/) Stress is ubiquitous and on the rise. How we learn to manage it can have profound effects on our health and well being. This series explains how our bodies experience stress and demonstrates effective strategies to help you thrive in a fast-paced world. On this edition, Jason Satterfield, Director of Behavioral Medicine at UCSF, explores adjustment to chronic medical and stress-induced illnesses, HIV, and stress-management. Series: "UCSF Osher Mini Medical School for the Public" [3/2008] [Health and Medicine] [Show ID: 13723]
  • Category

  • License

    • Standard YouTube License






Results Published from First Human Clinical Trials of “Anti-LINGO” Myelin Repair Strategy : National Multiple Sclerosis Society

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Results Published from First Human Clinical Trials of “Anti-LINGO” Myelin Repair Strategy

August 27, 2014
Results from two phase I human safety trials of an exploratory treatment aimed at repairing myelin damaged by multiple sclerosis have now been published. One to two treatments with Biogen Idec’s BIIB033 (anti-LINGO monoclonal antibody) were given by injection under the skin or into the vein of healthy volunteers and people with relapsing-remitting or secondary-progressive MS. No serious adverse safety events were reported, and although these studies were not designed to evaluate effectiveness, the results were considered positive and have led to a phase II trial, now underway in relapsing MS. The results were published on August 27, 2014 in the online journal Neurology® Neuroimmunology & Neuroinflammation.
“It’s encouraging to see an entirely new treatment strategy aimed at repairing MS myelin damage moving forward in clinical trials,” noted Dr. Timothy Coetzee, Chief Advocacy, Services and Research Officer at the National MS Society. “Repairing myelin may be the best way to protect the nervous system from MS damage, and it holds potential for restoring function that has been lost in people living with this disease,” he added.
Background: In MS, immune attacks lead to the loss of myelin that coats and protects nerve fibers in the brain and spinal cord. Repairing the nervous system was just a dream a few years ago. Today it holds significant promise as a strategy to restore the function that MS has taken from people; and reducing or stopping MS progression. This remarkable progress is due in large part to the National MS Society’s comprehensive efforts and multi-million dollar research investments. Today the Society is supporting 87 research projects in nervous system repair, with multi-year commitments totaling over $35 million.
The first human trials of anti-LINGO leverage research aimed at stimulating the body's natural healing abilities. LINGO is a protein seen in neurons and myelin-producing cells (oligodendrocytes), and blockading this protein with a monoclonal antibody called anti-LINGO has been shown to promote remyelination in animal models.
Details: In these first tests of anti-LINGO in humans, 72 healthy people and 47 people with relapsing-remitting MS or secondary-progressive MS were given anti-LINGO or inactive placebo by injection under the skin or into the vein. The participants with MS were given two treatments, two weeks apart.
All participants were monitored extensively for any signs of adverse reactions. There were no serious adverse safety events noted. The most common side effects included headache, upper respiratory tract infection, stuffy nose, GI symptoms and urinary tract infection, and these were experienced by participants who were on placebo as well as those who received doses of anti-LINGO.
Generally phase I studies are not designed to detect benefit, but largely to evaluate the safety and tolerability of exploratory therapies, to refine appropriate dosing, and to determine whether they reach their targets – in this case, the central nervous system. That is true of these trials, and there was no evidence from MRI or other tests that showed clear evidence that existing brain lesions healed from this short exposure to anti-LINGO. However, the safety, dosing and pharmacology results were considered positive and have led to the design and launch of a phase II trial by Biogen Idec, now underway in relapsing MS.
Read more about research into nervous system repair in MS.

About Multiple Sclerosis

Multiple sclerosis, an unpredictable, often disabling disease of the central nervous system, interrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.










Results Published from First Human Clinical Trials of “Anti-LINGO” Myelin Repair Strategy : National Multiple Sclerosis Society:



SOURCE: http://www.nationalmssociety.org/About-the-Society/News/Results-Published-from-First-Human-Clinical-Trials



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